A new study has found that gabapentin, a drug prescribed to millions for nerve pain and epilepsy, might be associated with a higher risk of dementia. The research, conducted by Case Western Reserve University, examined long-term users and found alarming trends in cognitive decline.
The study followed 26,000 patients with chronic back pain who took gabapentin over two decades. Those who took the medication six or more times had a 29% higher risk of dementia within ten years, while those with twelve or more prescriptions saw a 40% increase. Mild cognitive impairment was even more strongly linked, with frequent users facing an 85% higher risk.
Interestingly, the risk was highest in middle-aged adults (35-49), whose chances of dementia more than doubled. Younger patients (18-34) showed no significant increase, suggesting age may play a role. However, researchers stress that the study only shows a correlation—not proof that gabapentin causes dementia.
Critics of the study highlight its limitations. The research didn’t track exact dosages or consider lifestyle factors like physical inactivity, which is common in chronic pain patients and a known dementia risk. Dr. Leah Mursaleen of Alzheimer’s Research UK cautioned against jumping to conclusions, noting that more research is needed.
Gabapentin works by calming nerve activity, but its long-term effects on the brain remain unclear. Despite the findings, experts warn patients not to stop taking the medication without consulting a doctor, as sudden changes could worsen their condition.
